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cheap canada goose uk Credit: Jennifer Mckellar/IPSBy Ignatius BandaCAPE TOWN, South Africa, Dec 9 2013 (IPS)New research suggests that some AIDS patients are developing drug intolerance and severe side effects and will now have to switch to new, more expensive antiretroviral regimens.Researchers in Zimbabwe, Uganda, Nigeria and Malawi say some patients on the first line antiretroviral drugs nevirapine and efavirenz (EFZ) are showing signs of being intolerant to the two drugs.Daniel Sibanda, a University of Zimbabwe researcher, said while not many studies had been carried out on drug intolerance and side effects of antiretroviral therapy (ART), new research had found that there are toxicity concerns for some patients. »Our research has found that female patients with high CD4 Counts had developed nevirapine toxicity, » Sibanda told the 17th International Conference on AIDS and STIs in Africa currently taking place in Cape Town, South Africa. « This means they must switch to other drug regimes but these could be expensive alternatives. »These new concerns come just as Zimbabwe adopts new World Health Organisation (WHO) guidelines, which revised the recommended threshold for enrolling patients on ART from a CD4 count of 350 to 500. The new guidelines have expanded the number of Zimbabweans needing ART from around 800,000 to more than 1.2 million, according to the Ministry of Health and Child Welfare.The challenge of paying for this expanded treatment coverage is complicated by the possibility that some patients will need different medication. »These (nevirapine) are first line drugs and when patients are then switched to other drugs because of toxicity this could present problems for a country such as Zimbabwe because these drugs are expensive and are not available as free ARVs, » Sibanda told IPS.In Malawi, one of the countries with the highest number of people living with HIV, according to the United Nations Joint United Nations Programme on HIV/AIDS, some patients are experiencing side effects from EFZ.Dr cheap canada goose uk.

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